Doctor HealthHealth Tips

Opting for less damaging treatments, staying active and learning about the warning signs of lymphedema: that’s how women with breast cancer can avoid developing chronic lymphedema, according to the German Institute for Quality and Efficiency in Health Care (IQWiG).
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DiaGenic ASA (OSL: DIAG) and Applied Biosystems Inc. (NYSE: ABI) today announced the launch of BCtect(TM), a blood-based test for early detection of breast cancer. The test searches for a unique gene expression signature identified by DiaGenic using a custom TaqMan(R) Array manufactured for DiaGenic by Applied Biosystems. India was chosen as the first country for the introduction of BCtect(TM) after successful completion of a large study in the country.

The DiaGenic BCtect(TM) test addresses a significant medical need in India, where breast cancer is the second leading cause of death among women. The lack of a coordinated national screening program means that breast cancer is typically detected at a late stage, resulting in high mortality rates compared to Western countries. Last year alone, nearly 100,000 women in the country died from the disease. Breast cancer is also on the rise, with an estimated 250,000 new cases expected in India by 2015. A key problem has been the detection of only 10% of cases at an early stage, which lags far behind Western countries where detection rates reach as high as 65%.
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It’s been a stressful two years for Barack Obama. He’s campaigned nonstop, day-to-day, hour-to-hour, flying to different states and sleeping in different time zones. He’s also had to fight off the typical character attacks and mudslinging that hit any candidate for office.

And, on the eve of the election, his grandmother, a woman he credits for helping to raise him, died of cancer.

As studies have shown and many a doctor has seen with his own eyes, stress takes a toll on the body. It can lead to premature aging, heart disease, stroke, high blood pressure, depression and cancer.

So how old is Obama? Biologically, he’s 47 years and 3 months old. But a program called Realage.com says his “true age” is at least 49 years and 8 months old. The Web site claims it can calculate your “true age” based on a myriad of factors, including how often you visit your doctor, what your vital signs are, how often you exercise, what you eat, what your extracurricular activities are, and how much stress you have in your life.

There are many unknowns concerning Obama’s health. What is known is that he’s been a smoker on and off for many years, he’s African American, he’s middle aged and, as his doctor attested to in a statement released earlier this year, he’s in excellent physical condition.
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In a puzzling twist, women who have a history of migraine headaches are far less likely to develop breast cancer than other women, U.S. researchers said on Thursday.

The study is the first to look at the relationship between breast cancer and migraines and its findings may point to new ways of reducing a woman’s breast cancer risk, they said.

“We found that, overall, women who had a history of migraines had a 30 percent lower risk of breast cancer compared to women who did not have a history of such headaches,” said Dr. Christopher Li of the Fred Hutchinson Cancer Research Center in Seattle, whose findings appear in the journal Cancer Epidemiology, Biomarkers and Prevention.

Li said the reduction in risk was for the most common types of breast cancers — those driven by hormones, such as estrogen-receptor positive breast cancer, which is fueled by estrogen, and progesterone-receptor positive breast cancer, which is fueled by progesterone.

Hormones also play a role in migraines, a brutal type of headache often accompanied by nausea, vomiting and heightened sensitivity to light and sound. Women are two to three times more likely than men to get migraines.

While it is not exactly clear why women with a history of migraines had a lower risk for breast cancer, Li and colleagues suspect hormones are playing a role.

“Women who have higher levels of estrogen in their blood have higher levels of breast cancer,” Li said in a telephone interview.

And he said migraines are often triggered by low levels of the hormone estrogen, such as when estrogen levels fall during a woman’s menstrual cycle.

Women who get migraines “may have a chronically lower baseline estrogen. That difference could be what is protective against breast cancer,” Li said.

For the study, Li and colleagues analyzed data from two studies of 3,412 post-menopausal women in the Seattle area, 1,938 of whom had been diagnosed with breast cancer and 1,474 of whom had no history of breast cancer. Women in the study provided information on their migraine history.

They found women who had reported a clinical diagnosis of migraine had a 30 percent reduced risk of developing hormonally sensitive breast cancers.

“Migraines are typically most severe among pre-menopausal women,” Li said. “This study was all post-menopausal women.”

He said that suggests the protective effect seen in women who get migraines may have a lasting effect at reducing breast cancer risk.

“While these results need to be interpreted with caution, they point to a possible new factor that may be related to breast-cancer risk,” Li said in a statement.

Breast cancer is the leading cause of cancer death among women worldwide, with an estimated 465,000 deaths annually, according to the American Cancer Society.
By: Reuters

Hot flushes, night sweats or painful joints may be good news for women taking hormone-based drugs for breast cancer — it may mean their tumors are less likely to return, researchers said on Thursday.

Women with any of these menopause-like symptoms after taking AstraZeneca’s breast cancer drug Arimidex or generic tamoxifen were 30 percent less likely to have their cancer return over the next nine years, they found.

“The treatment is designed to starve potential cancers of estrogen and these symptoms mean that there are lower levels of estrogen in the body,” said Jack Cuzick, an epidemiologist at Cancer Research UK, who led the study published in the journal Lancet Oncology.

“But it is too early to say whether having these symptoms is essential for the treatment to be effective. At the moment all we can say is that the symptoms indicate the likely success of the treatment.”

Breast cancer is the leading cause of cancer deaths among women worldwide, according to the American Cancer Society. The group estimates about 465,000 women died of breast cancer globally in 2007, and 1.3 million new cases were diagnosed.

Declining death rates from breast cancer in developed countries have been attributed to early detection through mammography screening and to improved treatment.

The researchers looked at some 4,000 post-menopausal women treated with either Arimidex, known generically as anastrozole, or the older cancer drug tamoxifen. Arimidex is one of a newer class of drugs called aromatase inhibitors that cannot be taken by women not yet through menopause.

Women who reported hot flushes, night sweats or painful joints within three months of treatment were more likely to remain free of their cancer and these early side effects may also help doctors more effectively target future treatment.

“Our main message is: No pain, no gain,” Ivana Sestak, a Cancer Research UK researcher who worked on the study, said in a telephone interview.

Sestak added the researchers do not know why some women responded differently but believe genetics is the likely explanation because every person metabolizes the drugs that cause a drop in estrogen differently .

By Reuters

Obesity can wreck a person’s health for many reasons. But for women, too much weight tacks on an additional danger: Studies have linked obesity and breast cancer in a variety of ways.

Doctors aren’t sure why this link exists and are trying to figure out what ties weight gain to breast cancer. But they are more and more convinced the link is there, and they are urging women to watch their weight and increase their exercise to help stave off what is the most common cancer among females, nonmelanoma skin cancer aside.

“There are a lot of factors we need to figure out,” said Dr. Jennifer A. Ligibel, of the Dana-Farber Cancer Institute in Boston. “There are a lot of things we don’t know.”

An estimated 182,500 women in the United States will be found to have invasive breast cancer in 2008, according to the American Cancer Society, and about 40,480 women will die from the disease this year. Currently, there are about 2.5 million breast cancer survivors in the United States.

Studies have found that, in general, obesity is linked to cancer. The higher a person’s body-mass index (BMI, a ratio of weight to height), the more likely she or he will develop cancer, according to recent research by scientists at the University of Manchester in England. Other studies have found similar links to increased body fat.

Still other studies have found that women with breast cancer are more likely to live shorter lives and suffer a recurrence of their cancer if they are overweight.

For example, in a recent study conducted at the University of Texas M.D. Anderson Cancer Center in Houston, more than two-thirds of women with stage III locally advanced breast cancer were either overweight or obese. The study also found that a greater proportion of obese patients were likely to be diagnosed with a rare and more deadly form of breast cancer, known as inflammatory breast cancer.

Scientists vary in their opinions on why this link exists, and what it means.

Some believe that obesity may make tumors harder to detect, so a woman’s breast cancer will be further developed before it is discovered.

“It could be because there’s more breast tissue, a lump would be less evident,” Ligibel said.

Researchers also believe that the systemic effects of obesity might do something to spur cancer on. For example, obesity or overweight can lead to fluctuations in hormone levels in the body.

“When women are heavier, their estrogen levels are higher,” Ligibel said. “That could be a pathway through which weight affects breast cancer. Other studies have shown that when insulin levels are high, there’s more chance a cancer will come back.”

Another link to obesity was found in a study from the University of North Carolina at Chapel Hill that showed that obese women are more likely to skip screenings for breast and cervical cancer. Without those screenings, women are less likely to catch breast cancer at a more treatable stage.

Debbie Saslow, director of breast and gynecologic cancer at the American Cancer Society, said it’s not completely clear what role obesity plays in breast cancer risk.

“For obesity, which is independent of breast size, I would think two factors would come into play,” Saslow said. “One, a positive, is that the breasts may be fattier, which would make a mammogram easier to read. The second, a negative, is indirect: Obese women are less likely to go to a doctor.”

Menopause appears to be a critical time, Ligibel said. Obesity creates a greater risk for breast cancer post-menopause, while pre-menopausal women actually have a reduced risk.

“Gaining weight around the time of menopause is a risk factor in developing breast cancer,” Ligibel said.

The increased risk of developing breast cancer and dying of it after menopause is believed due to increased levels of estrogen in obese women, said Colleen Doyle, director of nutrition and physical activity with the American Cancer Society.

There is good news. Studies have shown that exercise — 30 minutes to 60 minutes a day of moderate-to-high intensity physical activity — decreases breast cancer risk, Doyle said.

“Physical activity reduces breast cancer risk both directly, by decreasing circulating estrogens, and also indirectly, by helping with weight control,” she said. “Women are so concerned about breast cancer risk. Communicating that there are key things you can do to reduce risk — watch your weight and be more active — are valuable messages.”

Ligibel agreed, noting that exercise might be valuable enough to counteract the strain on the body caused by obesity.

“You might not need to lose weight if you exercise,” Ligibel said. “Exercise could affect the hormone levels and help keep cancer from occurring or recurring.”

By HealthDay

Breast cancer survivors who suffer from hot flashes can reduce these attacks significantly with hypnosis, a new study finds.

Hot flashes are a problem for many women who survive breast cancer. Not only do they cause discomfort, but they interrupt sleep, cause anxiety and affect a woman’s quality of life.

“This is a very encouraging study of hypnosis as a treatment for hot flashes in breast cancer survivors,” said Dr. Ted Gansler, director of Medical Content at the American Cancer Society, who was not involved in the study. “This is an important topic because of the high prevalence of these symptoms in breast cancer survivors, and because few other treatment options are both safe and effective for this population,” he added.

There have been some other studies of hypnosis and cancer that indicate that the treatment is useful, but currently underutilized, Gansler noted.

The report was published in the September issue of the Journal of Clinical Oncology.

For the study, researchers led by Gary Elkins, a professor of psychology at Baylor University, randomly assigned 60 breast cancer survivors who suffered from hot flashes to five weekly sessions of either hypnosis or no treatment.

During each session of hypnosis, women were given mental imagery and suggestions for relaxation and coolness. They were also told to disassociate themselves from hot flashes. In addition, they were taught to use positive suggestions and imagery during self-hypnosis.

Women who underwent hypnosis had an average 68 percent decrease in the frequency and severity of hot flashes, the researchers found. In addition, these women said they experienced less anxiety and depression. They also had significant improvements in sleep and their ability to perform daily activities, compared with women who received no treatment.

“Women are interested in alternatives to traditional hormone therapy and pharmacologic interventions, and this study demonstrates the feasibility and potential effectiveness of hypnosis as an alternative treatment,” the researchers concluded.

But since the control group received no treatment, it’s difficult to say whether some or even all of the improvement represents a “placebo effect,” Gansler noted. “However, the researchers reasonably suggest that the improvement is so substantial that it is unlikely to be due entirely to a placebo effect,” he said.

Nancy E. Avis, a professor in the department of social sciences and health policy at Wake Forest University School of Medicine, and author of an accompanying journal editorial, agreed that hot flashes are a symptom of cancer treatment that needs to be paid attention to.

“We don’t have good interventions for hot flashes,” Avis said. “We know that hormone therapy treats hot flashes, but women who have had breast cancer don’t want to take hormone therapy,” she said.

Many mind-body approaches are promising, Avis said. “The hypnosis study has impressive results, but we need more research,” she said. “Based on these small studies, we are not ready to say they work.”

Avis believes alternative approaches such as hypnosis are appealing to a lot of women. Many other approaches such as meditation and yoga are available at cancer centers, she noted.

“There is no reason to think they are not safe,” Avis said. “The advice is — try it — there is no harm in trying. As long as you do it with somebody who knows what they’re doing, there are no downsides,” she said.
By Steven Reinberg (HealthDay News)

Women who were bigger and longer babies may be more likely to develop breast cancer, researchers reported on Tuesday.

The study adds to evidence that, at least in some cases, something that happens in the womb may cause cancer later in life.

Previous research into links between birth size and breast cancer have proved inconsistent, but the findings published in the Public Library of Science journal PLoS Medicine are strong evidence that the two may be related.

“These findings provide strong evidence that birth size — in particular birth length — is a marker of a woman’s breast cancer risk in adulthood, although the mechanisms underlying this association are unclear,” Isabel dos Santos Silva of the London School of Hygiene and Tropical Medicine and colleagues wrote.

Breast cancer is the leading cause of cancer deaths among women worldwide, according to the American Cancer Society. The group estimates about 465,000 women died of breast cancer globally in 2007, and 1.3 million new cases were diagnosed.

Declining death rates from breast cancer in developed countries have been attributed to early detection through mammography screening and to improved treatment.

Dos Santos Silva and colleagues examined 32 studies comprising 600,000 women, mainly in developed countries. Their analysis included more than 22,000 women who had breast cancer.

After considering established risk factors such as age and late menopause, the researchers found a strong association with birth size, birth length and head circumference. Of the three, birth length showed the strongest link.

“The amount by which birth size affected breast cancer risk was not affected by allowing for other established risk factors,” the researchers wrote.

For example, women with recorded birth weights of 4 kilograms or more had a 12 percent higher chance of breast cancer than babies weighing 3 to 3.5 kilograms at birth, the study found.

The link between breast cancer and birth size appeared smaller when compared with other risk factors. The researchers estimated that birth size may be responsible for up to 5 percent of all women who develop breast cancer by the age of 80.

Some research has linked hormones such as estrogen and human growth hormone with cancer.

The researchers noted age of puberty and adult height are also associated with breast cancer risk, and growth as a fetus can predict a girl’s growth, so there could be a link there.

“The maternal and/or foetal hormonal environment associated with large birth size may alter programing of the breast, making it more susceptible to cancer,” the researchers wrote.

by Michael Kahn | Maggie Fox and Tim Pearce ( LONDON Reuters )

Is there a link between moisturizers and skin cancer?

According to a new study by researchers at Rutgers University in New Jersey, several commonly used skin creams may cause skin tumors – at least in mice, Reuters reported.

Dr. Allan Conney, professor of cancer and leukemia research at Rutgers, discovered the risk while testing a theory that caffeine could prevent skin cancer, according to the report.

“We sort of got into this by accident,” Conney told Reuters. “We wanted a safe cream that we could put the caffeine into.”
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When someone well-known such as Christina Applegate is diagnosed with breast cancer, many adult women become concerned as to what the future holds for them.

While it’s true that 1 out of 8 American women will be diagnosed with breast cancer at some point in her lifetime, there are also a lot of misconceptions about the disease floating around.

Although Applegate is just 36 years old, the fact remains that breast cancer is more likely to strike women over the age of 50.

Still, many women under the age of 40 may now be tempted to run out and demand mammograms.

But mammograms are ineffective for most young women, Dr. Diana Zuckerman, president of the National Research Center for Women & Families, told FOXNews.com in October.

“Young women’s breasts are dense and if they get mammograms, their breasts show up very white on mammograms and cancer shows up as white,” she said. “But, as women get older, their breasts are less dense and show up gray on a mammogram, which makes it easy to identify the white cancer. If there is a family history, and women are worried, they can start earlier and in this case a digital mammography may work better than a traditional mammography.”

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